Synovial fluid matrix metalloproteinase‐3 levels are increased in inflammatory arthritides whether erosive or not
نویسندگان
چکیده
منابع مشابه
Increased serum proMMP-3 in inflammatory arthritides: a potential indicator of synovial inflammatory monokine activity.
OBJECTIVE To investigate if the increased concentrations of stromelysin (MMP-3) found in the synovial fluid (SF) of patients with various arthritides reflect the concentrations in the circulation. METHODS Using a double antibody ELISA, we have measured proMMP-3 concentrations in sera from these patient groups and in others with a heightened acute phase response (APR) as a result of multiple o...
متن کاملLevels of chemerin and interleukin 8 in the synovial fluid of patients with inflammatory arthritides and osteoarthritis.
OBJECTIVES Chemerin and interleukin (IL)-8 are pro-inflammatory mediators whose role in joint inflammation and cartilage degradation has been demonstrated in in-vitro findings. Studies on their presence in synovial fluid (SF) samples may offer further information on their pathogenic role. The aim of this study was to investigate SF chemerin and IL-8 levels in patients with different joint disea...
متن کاملHypoxanthine, xanthine, and urate in synovial fluid from patients with inflammatory arthritides.
As nucleotide catabolism increases during tissue injury the appearance of purine metabolites in inflamed synovial fluid might be of value in understanding the joint damage in inflammatory arthritides. In this study, therefore, synovial and plasma concentrations of hypoxanthine, xanthine, and urate in 16 patients with rheumatoid arthritis (three with psoriatic arthropathy) were analysed. It was ...
متن کامل14-3-3 Protein is Detectable in Blood Serum and Fetlock Joint Synovial Fluid of High Performance Horses
Objective: To investigate whether 14-3-3 eta protein is detectable in synovial fluid and blood serum of high performance horses and to study whether any significant correlation between this and matrix metalloproteinase 1 and 3 in horse synovial fluid. Design: Clinical study. Animals: Eleven standard breed horses (seven high performances and four controls). Procedures: Blood serum and fetlock...
متن کاملSuperoxide dismutase isoenzymes of the synovial fluid in rheumatoid arthritis and in reactive arthritides.
The activity of superoxide dismutase isoenzymes was determined in knee joint synovial fluid from 21 patients with rheumatoid arthritis, nine patients with reactive arthritides, and from 17 patients before arthroscopy or arthrotomy for suspected meniscal or ligament injury (controls). Extracellular superoxide dismutase was the major isoenzyme and accounted for about 80% of the total superoxide d...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2000
ISSN: 1462-0332,1462-0324
DOI: 10.1093/rheumatology/39.12.1357